Developing a Screening Test to Identify Women at Risk of Preeclampsia

Grant number: 2000732 | Funding period: 2021 - 2023

Completed

Abstract

Preeclampsia is a serious complication of pregnancy for which there is currently no cure and no way to accurately predict women at risk. Using large collections of human blood samples, we will screen for novel proteins within pregnant women's blood. We will then use artificial intelligence to select the best biomarkers and combine them with clinical information to develop a multi-marker blood test to predict women at risk.

Related publications (13)

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Thrombospondin-1 (THBS1) is dysregulated in preeclampsia

SM Botha, LA Bartho, S Hartmann, P Cannon, A Nguyen, TV Nguyen, N Pritchard, R Dechend, O Nonn, S Tong, TJ Kaitu'u-Lino

2026-02-01

Introduction: Preeclampsia involves endothelial dysfunction and impaired angiogenesis. Thrombospondin-1 (THBS1), a pro-thrombotic ..

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Alpha-fetoprotein (AFP) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants

J Masci, M Kandel, SP Walker, P Cannon, TV Nguyen, GP Wong, TM MacDonald, NJ Hannan, TJ Kaitu'u-Lino, LA Bartho

2025-04-17

Alpha-fetoprotein (AFP) is a protein commonly used to screen for aneuploidy in pregnancy. This study measured circulating AFP in m..

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Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia

SM Botha, LA Bartho, S Hartmann, P Cannon, A Nguyen, TV Nguyen, N Pritchard, R Dechend, O Nonn, S Tong, TJ Kaitu’u-Lino

2025-01-01

Preeclampsia results from placental insufficiency and causes maternal endothelial dysfunction and multi-organ damage. Our in-silic..

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Plasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction

Lucy A Bartho, Daniel R McKeating, Susan P Walker, Brunda Nijagal, Teresa M MacDonald, Natasha Pritchard, Natalie J Hannan, Anthony V Perkins, Stephen Tong, Tu’uhevaha J Kaitu’u-Lino

2024-07-09

Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide ..

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Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses

Lucy A Bartho, Susan P Walker, Ping Cannon, Tuong-Vi Nguyen, Anna Nguyen, Stefan M Botha, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2024-01-01

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR..

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Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant

LA Bartho, E Keenan, SP Walker, TM MacDonald, B Nijagal, S Tong, TJ Kaitu'u-Lino

2023-08-01

Background: Lipids serve as multifunctional metabolites that have important implications for the pregnant mother and developing fe..

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Circulating Chemerin Is Elevated in Women with Preeclampsia

LA Bartho, M Kandel, SP Walker, CA Cluver, R Hastie, L Bergman, N Pritchard, P Cannon, TV Nguyen, GP Wong, TM Macdonald, E Keenan, NJ Hannan, S Tong, TJ Kaitu'U-Lino

2023-05-01

Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly e..

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Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction

F Andres, NJ Hannan, SP Walker, TM MacDonald, GP Wong, C Murphy, P Cannon, M Kandel, J Masci, TV Nguyen, A Abboud, D Idzes, V Kyritsis, N Pritchard, S Tong, TJ Kaitu’u-Lino

2022-12-01

Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize end..

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Placental galectin-3 is reduced in early-onset preeclampsia

M Kandel, S Tong, SP Walker, P Cannon, TV Nguyen, TM MacDonald, NJ Hannan, TJ Kaitu’u-Lino, LA Bartho

2022-10-14

Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside ..

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PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

M Kandel, TM Macdonald, SP Walker, C Cluver, L Bergman, J Myers, R Hastie, E Keenan, NJ Hannan, P Cannon, TV Nguyen, N Pritchard, S Tong, TJ Kaitu’u-Lino

2022-04-05

BACKGROUND: Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomark- ers ar..

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Circulating Activin A is elevated at 36 weeks' gestation preceding a diagnosis of preeclampsia

Georgia P Wong, Faith Andres, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Emerson Keenan, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2022-03-01

Activin A is aberrantly expressed by the preeclamptic placenta and circulating levels have been investigated as a potential biomar..

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A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants: ADAM12 is reduced in SGA

F Andres, GP Wong, SP Walker, TM MacDonald, E Keenan, P Cannon, TV Nguyen, NJ Hannan, S Tong, TJ Kaitu'u-Lino

2022-01-01

First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and preeclampsia. We measured plasma ADAM12 at 36 ..

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Elevated circulating and placental SPINT2 is associated with placental dysfunction

CN Murphy, SP Walker, TM Macdonald, E Keenan, NJ Hannan, ME Wlodek, J Myers, JF Briffa, T Romano, A Roddy Mitchell, CA Whigham, P Cannon, TV Nguyen, M Kandel, N Pritchard, S Tong, TJ Kaitu’u-lino

2021-07-02

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functi..